Collie Eye Anomaly CEA/CH :
Collie Eye Anomaly (CEA), also known as Choroidal Hypoplasia (CH), is an inherited eye disorder which stops the choroid developing normally. Dogs can be examined at a young age (between 5 and 8 weeks) with an ophthalmoscope, and in many cases CEA can be diagnosed if present. Severe cases can lead to loss of vision, although rarely result in total blindness.

Research at Cornell University and at The Fred Hutchinson Cancer Research Center uncovered the disease gene, and the disease causing mutation. The mutation follows the inherited recessive pattern, i.e. the parents of an affected offspring must at least carry the mutation themselves (they could also be affected). Due to the discovery of the gene, a DNA test is possible to determine not only affected dog, but also carriers of the disease (in whom the disease will never be present, but who may pass the mutation onto their offspring). Our Software makes use of the results of this DNA test to infer probabilities of being affected or carrying the mutation. The result of dogs whose genotype is known (either through a DNA test or by being diagnosed affected by a vet) appears with a thick outline in the genetic propagation diagram. For these dogs, the word Tested appears in the corresponding CEA field. Probabilities for untested dogs are inferred automatically and are presented with a thin outline in the genetic propagation diagram.

More information you can find here on these web sites :
bordercolliehealth.com/CEAdatabase
www.optigen.com
www.oog-dierenarts.be