Neuronal Ceroid Lipofuscinosis Cl :

Ceroid Lipofuscinosis (CL) in the Border Collie is a rare disease which affects the nerve cells of the body. The disease may result in death. It is inherited and follows the inherited recessive pattern, which means that the parents of an affected offspring must both be either carriers or affected themselves.

Research at the University of New South Wales has uncovered the disease gene, and the disease causing mutation. Due to the discovery of the gene, a DNA test is possible to determine not only affected dog, but also carriers of the disease (in whom the disease will never be present, but who may pass the mutation onto their offspring).
Our Software makes use of the results of this DNA test to infer probabilities of being affected or carrying the mutation. The result of dogs whose genotype is known (either through a DNA test or by being diagnosed affected by a vet) appears with a thick outline in the genetic propagation diagram. For these dogs, the word Tested appears in the corresponding CL field. Probabilities for untested dogs are inferred automatically and are presented with a thin outline in the genetic propagation diagram.

More information you can find here on this web site :
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